• Dab tsi yogPQQ ?
PQQ, lub npe tag nrho yog pyrroloquinoline quinone. Zoo li coenzyme Q10, PQQ kuj yog coenzyme ntawm reductase. Nyob rau hauv daim teb ntawm kev noj haus tshuaj, nws feem ntau tshwm sim raws li ib koob tshuaj (nyob rau hauv daim ntawv ntawm disodium ntsev) los yog nyob rau hauv daim ntawv ntawm cov khoom ua ke nrog Q10.
Lub ntuj tsim ntawm PQQ yog tsawg heev. Nws muaj nyob rau hauv cov av thiab cov kab mob, cov nroj tsuag thiab tsiaj cov ntaub so ntswg, xws li tshuaj yej, natto, kiwifruit, thiab PQQ kuj muaj nyob rau hauv tib neeg cov ntaub so ntswg.
PQQmuaj ntau yam physiological functions. Nws tuaj yeem txhawb nqa mitochondria tshiab hauv cov hlwb (mitochondria hu ua "zog ua cov nroj tsuag ntawm cov hlwb"), yog li ntawd qhov ceev ntawm cell zog synthesis tuaj yeem nce siab heev. Tsis tas li ntawd, PQQ tau raug lees paub hauv kev tshawb fawb tsiaj thiab tib neeg los txhim kho kev pw tsaug zog, txo cov roj cholesterol, txo oxidative kev nyuaj siab, ua kom lub neej ntev, txhawb lub hlwb ua haujlwm thiab txo qhov mob.
Nyob rau hauv 2017, ib pab neeg tshawb fawb tsim los ntawm xibfwb Hiroyuki Sasakura thiab lwm tus los ntawm Nagoya University hauv Nyij Pooj tau luam tawm lawv cov kev tshawb fawb hauv phau ntawv journal "JOURNAL OF CELL SCIENCE". Cov coenzyme pyrroloquinoline quinone (PQQ) tuaj yeem ua rau lub neej ntawm nematodes.
• Cov txiaj ntsim kev noj qab haus huv yog dab tsiPQQ ?
PQQ Txhawb nqa Mitochondria
Hauv kev tshawb fawb tsiaj, cov kws tshawb fawb ntawm University of California pom tias PQQ tuaj yeem txhawb kev tsim cov mitochondria noj qab haus huv. Hauv txoj kev tshawb no, tom qab noj PQQ rau 8 lub lis piam, tus naj npawb ntawm mitochondria hauv lub cev ntau dua ob npaug. Hauv lwm txoj kev tshawb fawb tsiaj, cov txiaj ntsig tau pom tias kev tiv thaiv kab mob tau txo qis thiab tus naj npawb ntawm mitochondria raug txo kom tsis txhob noj PQQ. Thaum PQQ tau rov ntxiv, cov tsos mob no tau rov qab sai.
Txo qhov mob thiab tiv thaiv kev mob caj dabAntioxidant & paj tiv thaiv
Cov neeg laus feem ntau muaj teeb meem los ntawm kev mob caj dab, uas kuj yog ib qho tseem ceeb ua rau kev tsis taus. Cov kev tshawb fawb tau pom tias tag nrho cov neeg tuag ntawm cov neeg mob rheumatoid mob caj dab yog 40% siab dua li ntawm cov pej xeem. Yog li ntawd, lub zej zog kev tshawb fawb tau nquag nrhiav txoj hauv kev los tiv thaiv thiab kho mob caj dab. Ib txoj kev tshawb fawb tsis ntev los no tau luam tawm hauv phau ntawv Journal Inflamation qhia tiasPQQtej zaum yuav yog tus cawm seej mob caj dab uas cov kws tshawb fawb tau nrhiav.
Hauv kev sim tshuaj tib neeg, cov kws tshawb fawb sim simulated chondrocyte o nyob rau hauv lub raj kuaj, txhaj PQQ rau hauv ib pawg ntawm cov hlwb, thiab tsis txhaj rau lwm pab pawg. Cov txiaj ntsig tau pom tias qib ntawm collagen degrading enzymes (matrix metalloproteinases) hauv cov pab pawg chondrocytes uas tsis tau txhaj nrog PQQ nce ntau.
Los ntawm kev tshawb fawb hauv vitro thiab hauv vivo, cov kws tshawb fawb tau pom tias PQQ tuaj yeem cuam tshuam qhov kev tso tawm ntawm cov kab mob sib kis los ntawm cov kab mob fibrotic synovial hauv cov pob qij txha, thaum inhibiting kev ua haujlwm ntawm cov khoom siv hluav taws xob uas ua rau mob. Nyob rau tib lub sijhawm, cov kws tshawb fawb tseem pom tias PQQ tuaj yeem txo cov haujlwm ntawm cov enzymes tshwj xeeb (xws li matrix metalloproteinases), uas ua rau hom 2 collagen hauv cov pob qij txha thiab puas pob qij txha.
Antioxidant & paj tiv thaiv
Cov kev tshawb fawb tau pom tiasPQQmuaj cov nyhuv neuroprotective rau nas midbrain neuronal puas thiab Parkinson tus kab mob tshwm sim los ntawm rotenone.
Mitochondrial dysfunction thiab oxidative kev nyuaj siab tau pom tias yog ob lub ntsiab culprits ntawm Parkinson tus kab mob (PD). Cov kev tshawb fawb tau pom tias PQQ muaj cov nyhuv antioxidant muaj zog thiab tuaj yeem tiv thaiv cerebral ischemia los ntawm kev tiv thaiv oxidative kev nyuaj siab. Cov lus teb oxidative kev ntxhov siab yog suav tias yog ib qho ntawm txoj hauv kev tseem ceeb tshaj plaws ua rau cell apoptosis. PQQ tuaj yeem tiv thaiv SH-SY5Y hlwb los ntawm rotenone (neurotoxic tus neeg saib xyuas)-induced cytotoxicity. Cov kws tshawb fawb siv PQQ pretreatment los tiv thaiv rotenone-induced cell apoptosis, restore mitochondrial membrane peev xwm, thiab inhibit zus tau tej cov intracellular reactive oxygen hom (ROS).
Feem ntau, kev tshawb fawb tob txog lub luag haujlwm ntawmPQQhauv kev noj qab haus huv ntawm lub cev tuaj yeem pab tib neeg kom tiv thaiv kev laus.
• NEWGREEN SupplyPQQPowder / Capsules / Tablets / Gummies
Post lub sij hawm: Oct-26-2024
