• Dab tsi yogTetrahydrocurcumin ?
Rhizoma Curcumae Longae yog cov rhizoma qhuav ntawm Curcumae Longae L. Nws yog dav siv los ua zaub mov xim thiab tshuaj tsw qab. Nws cov tshuaj muaj pes tsawg leeg muaj xws li curcumin thiab volatile roj, ntxiv rau saccharides thiab sterols. Curcumin (CUR), raws li ib tug natural polyphenol nyob rau hauv cov nroj tsuag curcuma, tau pom tias muaj ntau yam pharmacological teebmeem, xws li anti-inflammatory, antioxidant, oxygen dawb radical tshem tawm, daim siab tiv thaiv, anti-fibrosis, anti-tumor kev ua si thiab kev tiv thaiv. ntawm Alzheimer's disease (AD).
Curcumin yog metabolized sai sai hauv lub cev mus rau hauv glucuronic acid conjugates, sulfuric acid conjugates, dihydrocurcumin, tetrahydrocurcumin, thiab hexahydrocurcumin, uas nyob rau hauv lem yog hloov dua siab tshiab rau hauv tetrahydrocurcumin. Cov kev tshawb fawb soj ntsuam tau lees paub tias curcumin muaj kev ruaj ntseg tsis zoo (saib photodecomposition), dej solubility tsis zoo thiab tsis muaj bioavailability. Yog li ntawd, nws lub ntsiab metabolic tivthaiv tetrahydrocurcumin nyob rau hauv lub cev tau dhau los ua kev tshawb fawb hotspot nyob rau hauv tsev thiab txawv teb chaws nyob rau hauv xyoo tas los.
Tetrahydrocurcumin(THC), raws li cov nquag nquag thiab tseem ceeb metabolite ntawm curcumin tsim thaum lub sij hawm nws cov metabolism hauv vivo, tuaj yeem raug cais tawm ntawm cytoplasm ntawm txoj hnyuv thiab daim siab tom qab kev tswj hwm curcumin rau tib neeg lossis nas. Cov mis mos molecular yog C21H26O6, qhov hnyav molecular yog 372.2, qhov ceev yog 1.222, thiab melting point yog 95 ℃ -97 ℃.
• Cov txiaj ntsig yog dab tsiTetrahydrocurcuminHauv Kev Kho Hniav?
1. Cov nyhuv ntawm melanin ntau lawm
Tetrahydrocurcumin tuaj yeem txo cov ntsiab lus melanin hauv B16F10 hlwb. Thaum cov ntsiab lus sib thooj ntawm tetrahydrocurcumin (25, 50, 100, 200μmol / L) tau muab, cov ntsiab lus melanin poob ntawm 100% mus rau 74.34%, 80.14%, 34.37%, 21.40%, feem.
Tetrahydrocurcumin tuaj yeem inhibit tyrosinase kev ua haujlwm hauv B16F10 hlwb. Thaum qhov sib xyaw ua ke ntawm tetrahydrocurcumin (100 thiab 200μmol / L) tau muab rau cov hlwb, cov kev ua ntawm tyrosinase intracellular poob mus rau 84.51% thiab 83.38%, feem.
2. Anti-photoaging
Thov saib daim duab nas hauv qab no: Ctrl (tswj), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg / kg, yaj hauv 0.5% sodium carboxymethyl cellulose). Cov duab ntawm daim tawv nqaij tom qab KM nas ntawm 10 lub lis piam tom qab xaiv THC kho thiab UVA irradiation. Cov pab pawg sib txawv uas sib npaug UVA flux hluav taws xob rau lub teeb aging raug soj ntsuam los ntawm Bissett qhab nia. Cov txiaj ntsig tau nthuav tawm yog qhov piv txwv tus qauv sib txawv (N = 12 / pawg). *P<0.05, **P
Los ntawm cov tsos, piv nrog rau cov pab pawg tswj ib txwm, daim tawv nqaij ntawm cov qauv tswj pawg yog ntxhib, pom erythema, ulceration, wrinkles tob tob thiab thickened, nrog rau tawv-zoo li hloov, uas qhia ib tug raug photoaging phenomenon. Piv nrog rau cov qauv tswj pawg, kev puas tsuaj degree ntawmtetrahydrocurcumin100 mg / kg pawg tau qis dua li ntawm pawg tswj hwm tus qauv, thiab tsis muaj pob khaus thiab erythema pom ntawm daim tawv nqaij, tsuas yog pom me ntsis pigmentation thiab nplua wrinkles.
3.Cov tshuaj antioxidant
Tetrahydrocurcumin tuaj yeem nce qib SOD, txo LDH qib thiab nce GSH-PX qib hauv HaCaT hlwb.
Tshem tawm DPPH dawb radicals
CovtetrahydrocurcuminCov tshuaj yog diluted los ntawm 10, 50, 80, 100, 200, 400, 800, 1600 lub sij hawm successively, thiab cov qauv tov tau meej tov nrog 0.1 mmol / L DPPH tov ntawm qhov ratio ntawm 1: 5. Tom qab cov tshuaj tiv thaiv ntawm chav tsev kub rau 30min, tus nqi absorbance tau txiav txim siab ntawm 517nm. Cov txiaj ntsig tau pom hauv daim duab:
4. inhibit qhov mob ntawm daim tawv nqaij
Cov kev tshawb fawb sim tau pom tias qhov txhab kho mob ntawm nas tau pom tsis tu ncua rau 14 hnub, thaum THC-SLNS gel tau siv feem, qhov txhab kho qhov nrawm thiab cov txiaj ntsig ntawm THC thiab kev tswj tau zoo tau nrawm dua thiab zoo dua, qhov kev txiav txim qis dua yog THC-SLNS gel. >
THC > Kev tswj zoo.
Hauv qab no yog cov duab sawv cev ntawm tus qauv excised mob nas thiab cov kev soj ntsuam histopathological, A1 thiab A6 qhia cov tawv nqaij ib txwm, A2 thiab A7 qhia THC SLN gel, A3 thiab A8 qhia kev tswj zoo, A4 thiab A9 qhia THC gel, thiab A5 thiab A10 qhia cov khoom seem lipid nanoparticles (SLN), feem.
• Daim Ntawv Thov NtawmTetrahydrocurcuminHauv Tshuaj pleev ib ce
1. Cov khoom siv tawv nqaij:
Anti-Aging Khoom:Siv nyob rau hauv anti-aging cream thiab serums los pab txo wrinkles thiab zoo kab thiab txhim kho daim tawv nqaij elasticity.
Cov khoom ua kom dawb:Ntxiv rau whitening essences thiab cream los pab txhim kho cov tawv nqaij tsis sib xws thiab pob.
2.Anti-inflammatory khoom:
Siv rau hauv cov khoom tu tawv nqaij rhiab xws li soothing thiab kho cov tshuaj pleev kom txo tau qhov liab thiab khaus.
3. Cov khoom siv ntxuav:
Ntxiv rau cleansers thiab exfoliants los pab ntxuav cov tawv nqaij thiab muab cov tshuaj tua kab mob los tiv thaiv pob txuv.
4.Sunscreen Khoom:
Ua raws li cov tshuaj tiv thaiv antioxidant los txhim kho cov txiaj ntsig ntawm cov tshuaj pleev thaiv hnub thiab tiv thaiv daim tawv nqaij los ntawm UV rays.
5. Daim npog ntsej muag:
Siv nyob rau hauv ntau lub ntsej muag lub ntsej muag los muab cov khoom noj sib sib zog nqus thiab kho, txhim kho daim tawv nqaij zoo nkauj.
Tetrahydrocurcuminyog dav siv hauv tshuaj pleev ib ce, npog daim tawv nqaij, tu, tiv thaiv tshav ntuj thiab lwm yam. Nws yog txaus siab rau nws cov antioxidant, anti-inflammatory thiab whitening teebmeem.
Post lub sij hawm: Oct-10-2024
